{"id":5864,"date":"2022-02-25T17:13:25","date_gmt":"2022-02-25T14:13:25","guid":{"rendered":"https:\/\/vitroturkey.bio\/?p=5864"},"modified":"2022-02-25T17:20:29","modified_gmt":"2022-02-25T14:20:29","slug":"mikroorganizmalar-ve-antibiyotik-direnc-mekanizmalarinin-hizli-tespiti-icin-test-basariyla-dogrulanmistir","status":"publish","type":"post","link":"https:\/\/vitroturkey.bio\/tr\/mikroorganizmalar-ve-antibiyotik-direnc-mekanizmalarinin-hizli-tespiti-icin-test-basariyla-dogrulanmistir\/","title":{"rendered":"Mikroorganizmalar ve Antibiyotik diren\u00e7 mekanizmalar\u0131n\u0131n h\u0131zl\u0131 tespiti i\u00e7in test ba\u015far\u0131yla do\u011frulanm\u0131\u015ft\u0131r"},"content":{"rendered":"

Antibiyoti\u011fe \u00e7ok diren\u00e7li bakterilerin \u00e7o\u011falmas\u0131, 21. y\u00fczy\u0131l\u0131n en \u00f6nemli k\u00fcresel sa\u011fl\u0131k sorunlar\u0131ndan biridir. Ger\u00e7ekten de, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO), antimikrobiyal direnci (AMR)<\/strong> insanl\u0131\u011f\u0131n kar\u015f\u0131 kar\u015f\u0131ya oldu\u011fu ilk on halk sa\u011fl\u0131\u011f\u0131 tehdidinden biri olarak listelemi\u015ftir.<\/p>\n

The Lancet’te bu Ocak ay\u0131nda yay\u0131nlanan bir ara\u015ft\u0131rma, 2019’da antibiyotik direnciyle ili\u015fkili 4,95 milyon \u00f6l\u00fcm oldu\u011funu ve bunlar\u0131n 1,27 milyonunun do\u011frudan buna ba\u011fl\u0131 oldu\u011funu g\u00f6steriyor; bu rakam HIV veya s\u0131tma gibi hastal\u0131klardan bile daha y\u00fcksek bir rakam. Ulusal olarak, EPINE \u00e7al\u0131\u015fmas\u0131ndan elde edilen veriler (\u0130spanya’da Hastane Enfeksiyonlar\u0131n\u0131n Yayg\u0131nl\u0131\u011f\u0131 \u00c7al\u0131\u015fmas\u0131, 2019), sa\u011fl\u0131k hizmetiyle ili\u015fkili enfeksiyonlar\u0131n %17’sinin bir t\u00fcr antibiyoti\u011fe diren\u00e7li bakterilerden kaynakland\u0131\u011f\u0131n\u0131 ortaya koymu\u015ftur.<\/p>\n

Bu nedenle, diren\u00e7 mekanizmalar\u0131n\u0131 ve mikroorganizmalar\u0131 tespit etmeye yard\u0131mc\u0131 olan y\u00f6ntemlerle bu \u201csessiz pandemi\u201d ile m\u00fccadele etmek \u00f6nemlidir. Vitro S.A<\/a>., antibiyotiklere kar\u015f\u0131 \u00e7ok diren\u00e7li bu bakterilerin h\u0131zl\u0131 tespiti i\u00e7in<\/strong> MDR Direct Flow Chip<\/strong> Kit<\/strong>‘i sunar ve d\u00f6rt saatten k\u0131sa s\u00fcrede sonu\u00e7 verir.<\/p><\/blockquote>\n

Sevilla’daki Virgen del Roc\u00edo \u00dcniversite Hastanesi Enfeksiyon Hastal\u0131klar\u0131, Mikrobiyoloji ve \u00d6nleyici T\u0131p Klinik Birimi’nden Dr \u00c1ngel Rodr\u00edguez Villodres’in belirtti\u011fi gibi, \u201cuygun olmayan antibiyotik tedavilerinin kullan\u0131lmas\u0131, hastanede kal\u0131\u015f s\u00fcresinin ve hasta \u00f6l\u00fcmlerinin artmas\u0131yla do\u011frudan ili\u015fkilidir. Bu nedenle antibiyoti\u011fe diren\u00e7li mikroorganizmalar\u0131n erken tespiti, antibiyotik tedavisini do\u011fru almak \u00e7ok \u00f6nemliyken, enfeksiyonun ilk saatlerinde uygun olmayan antibiyotik tedavilerinin neden oldu\u011fu terap\u00f6tik ba\u015far\u0131s\u0131zl\u0131k \u015fans\u0131n\u0131 azaltmam\u0131z\u0131 sa\u011flar\u201d.<\/p>\n

Kit ayn\u0131 zamanda tek bir tahlilde toplam altm\u0131\u015f molek\u00fcler hedefi<\/strong> (be\u015fi en \u00f6nemli \u00e7oklu diren\u00e7li bakterileri spesifik olarak tan\u0131mlamak i\u00e7in) ve hastane ortam\u0131nda yayg\u0131n olarak kullan\u0131lan 55 antibiyotik diren\u00e7 belirteci<\/strong> (dokuz tanesine ait farkl\u0131 antibiyotik s\u0131n\u0131flar\u0131) saptamak i\u00e7in kullan\u0131labilir.<\/p><\/blockquote>\n

Kitin etkinli\u011fi Sevilla’daki Virgen del Roc\u00edo Hastanesinde do\u011frulanm\u0131\u015ft\u0131r. Hem klinik izolatlarda (bakteri kolonilerinin do\u011frudan kullan\u0131m\u0131) hem de klinik \u00f6rneklerde do\u011fru \u00e7al\u0131\u015ft\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir: pozitif kan k\u00fclt\u00fcrleri, rektal eks\u00fcdalar ve nazofaringeal eks\u00fcdalar. Uzman, “MDR Do\u011frudan Ak\u0131\u015f \u00c7ip Kiti gibi ara\u00e7lar\u0131n hastalar i\u00e7in ampirik antibiyotik tedavisini optimize ederek enfeksiyonun daha iyi prognozuna ve dolay\u0131s\u0131yla bu t\u00fcr enfeksiyonla ili\u015fkili \u00f6l\u00fcm oran\u0131n\u0131 d\u00fc\u015f\u00fcrmesine yol a\u00e7mas\u0131 umulmaktad\u0131r” diye belirtiyor.<\/p>\n

Klinik do\u011frulama \u00e7al\u0131\u015fmalar\u0131nda ve 198 farkl\u0131 numuneyi analiz ettikten sonra, MDR Direct Flow Chip Kit<\/strong>, molek\u00fcler d\u00fczeyde tespit edilen diren\u00e7 belirte\u00e7leri ile rutin fenotipik karakterizasyon y\u00f6ntemleriyle elde edilen klinik izolatlar\u0131n sergiledi\u011fi antibiyotik duyarl\u0131l\u0131k profili aras\u0131nda ola\u011fan\u00fcst\u00fc bir korelasyon g\u00f6stermi\u015ftir.<\/p>\n

Bu nedenle MDR Direct Flow Chip Kit’in tan\u0131 s\u00fcresini k\u0131saltt\u0131\u011f\u0131, yani mikrobiyoloji hizmetlerinde uygulanmas\u0131n\u0131n hasta y\u00f6netimini optimize etmeye ve terap\u00f6tik ba\u015far\u0131s\u0131zl\u0131klar\u0131 \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fi anlam\u0131na geldi\u011fi onaylanm\u0131\u015ft\u0131r. Antimikrobiyal direncin yay\u0131lmas\u0131n\u0131n ve geni\u015f spektrumlu antibiyotiklerin a\u015f\u0131r\u0131 kullan\u0131m\u0131n\u0131n \u00f6nlenmesinde de faydal\u0131 olabilir.<\/p>\n","protected":false},"excerpt":{"rendered":"

Antibiyoti\u011fe \u00e7ok diren\u00e7li bakterilerin \u00e7o\u011falmas\u0131, 21. y\u00fczy\u0131l\u0131n en \u00f6nemli k\u00fcresel sa\u011fl\u0131k sorunlar\u0131ndan biridir. Ger\u00e7ekten de, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO), antimikrobiyal direnci (AMR) insanl\u0131\u011f\u0131n kar\u015f\u0131 kar\u015f\u0131ya oldu\u011fu ilk on halk sa\u011fl\u0131\u011f\u0131 tehdidinden biri olarak listelemi\u015ftir. The Lancet’te bu Ocak ay\u0131nda yay\u0131nlanan bir ara\u015ft\u0131rma, 2019’da antibiyotik direnciyle ili\u015fkili 4,95 milyon \u00f6l\u00fcm oldu\u011funu ve bunlar\u0131n 1,27 milyonunun do\u011frudan…<\/p>\n","protected":false},"author":8,"featured_media":5862,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[28],"tags":[],"_links":{"self":[{"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/posts\/5864"}],"collection":[{"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/comments?post=5864"}],"version-history":[{"count":2,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/posts\/5864\/revisions"}],"predecessor-version":[{"id":5866,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/posts\/5864\/revisions\/5866"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/media\/5862"}],"wp:attachment":[{"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/media?parent=5864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/categories?post=5864"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vitroturkey.bio\/tr\/wp-json\/wp\/v2\/tags?post=5864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}